Prioritised clinical domain
Nil
Abbreviation
PRELUDE
Registry contact
Danielle Crimmins, Princess Alexandra Hospital, Metro South Hospital and Health Service, danielle.crimmins@health.qld.gov.au
Year established
2026
Description
PRELUDE is a prospective, multi-site observational pilot registry study designed to assess the feasibility, utility, and epidemiological value of a perioperative anaphylaxis registry in Queensland. This data set will support pharmacovigilance and evidence based anaesthetic drug selection, as well as resource planning and workforce development at both the state and national levels.
PRELUDE will:
- Establish current incidence rates of perioperative hypersensitivity reactions, and calculate the rate of hypersensitivity per anaesthetic procedure
- Identify implicated drug classes, and calculate the rate of hypersensitivity per drug exposure
- Report severity of reactions
- Assess current management of reactions against guidelines
- Develop and refine a minimum registry dataset suitable for national adoption
- Integrate data collection into existing clinical workflows
- Monitor patient inclusion and consent rates
- Assess data quality and clinician engagement
- Estimate operational and financial requirements for national rollout.
Reporting process
- Feedback to contributing clinicians
- Reported in Annual Report
- Reported in other public reports
Patient Reported Outcome Measures (PROMs)
Nil
Patient Reported Experience Measures (PREMs)
Nil
Participating sites
Queensland
- Cairns Base Hospital
- Compass Immunology
- Gold Coast University Hospital
- Logan Hospital
- Princess Alexandra Hospital
- Queensland Anaesthetic Reaction Clinic
- Queensland Children's Hospital
- Royal Brisbane & Womens Hospital
- Sunshine Coast University Hospital
- The Centre for the Business and Economics of Health (University of Queensland)
- Townsville University Hospital
Condition
Perioperative allergy and hypersensitivity
Name
Pilot Registry Evaluating Large-scale Understanding of Drug Events
Weblink
Nil
Lead organisation
Metro South Hospital and Health Service, Queensland Health
Ethics approval reference
Metro South Health Human Research Ethics Committee (MSH HREC) Approval HREC/2025/QMS/120799
Program area
Preferred published date
Immediately