Carbapenemase-producing Enterobacteriaceae (CPE) Guide

Enterobacteriaceae are the largest family of gram-negative bacteria causing human infection. CPE are members of the Enterobacteriaceae that are resistant to carbapenems, a class of ‘last resort’ antibiotics used for treating serious infections.

In 2017, the Commission updated recommendations for the management and testing of patients with carbapenemase-producing Enterobacteriaceae (CPE). This work was done in partnership with the Australasian Society of Infectious Diseases, Australasian College of Infection Prevention and Control, Public Health Laboratory Network and Australasian Society of Antimicrobials.

Subsequently, taxonomic studies have narrowed the definition of the family Enterobacteriaceae. Some previous members of this family are now included in other families within the order Enterobacterales, and this term is now used in many publications (i.e. carbapenemase-producing Enterobacterales).

The guide is divided into 5 sections: Planning, preparation and prevention; CPE screening and surveillance; Strategies to reduce CPE transmission; Outbreak management; and Laboratory screening and confirmation methods.

Supporting resources

The following resources have also been developed to support the implementation of the CPE guide: