Gram-negative bacteria – including Enterobacteriaceae – that are resistant to most, or all, types of antibiotics have emerged as a significant global public health threat. Resistance to carbapenem antibiotics is of particular concern. Multi drug resistant gram-negative bacteria, including carbapenemase producing Enterobacteriaceae (CPE), place Australian patients at greater risk of potentially untreatable infection and increased mortality.

The Commission worked in partnership with the Australasian Society of Infectious Diseases, Australasian College of Infection Prevention and Control, Public Health Laboratory Network and Australasian Society of Antimicrobials to update the recommendations for the management and testing of patients with CPE.

The CPE Guide is divided into 5 sections: Planning, preparation and prevention; CPE screening and surveillance; Strategies to reduce CPE transmission; Outbreak management; and Laboratory screening and confirmation methods. The Guide includes recommendations for patient management in the Australian Guidelines for the Prevention and Control of Infection in Healthcare and the National Safety and Quality Health Service Standards have been incorporated into the guide.

Download the Recommendations for the control of Carbapenemase-producing Enterobacteriaceae (PDF 3MB)

Download supporting information and resources:

Control of CPE: Information for patients (PDF 173KB) (Word 761KB)

Control of CPE: Checklist for ward staff and after hours managers (PDF 255KB) (Word 1MB)

Control of CPE: Information for clinicians and health service managers  (PDF 227KB) (Word 761KB)

Control of CPE: Information for clinicians  (PDF 178KB) (Word 340KB)